The cheapest Prague to Chicago return flight on the radar right now is €762, flying with LOT via one or more connections. It covers departures in March 2027, and every dated link below opens that exact PRG–ORD search on Skyscanner. The price we usually record on this route is €631. Across 100 recorded checks it has ranged between €263 and €1,008. Our sampling points to March 2027 as the cheapest month to fly Prague to Chicago.
Every fare here is re-confirmed against Skyscanner automatically, and each one is stamped with the moment it was last checked, so you can see how fresh it is instead of taking it on trust. Not flying from Prague? We track 61 other departure cities for Chicago, listed at the foot of this page.
Fares move quickly. If this Prague to Chicago price has gone by the time you search, shift the dates a day or two either side, because the same route is often still cheap just next door.