Cheap open jaw flights from European cities to South America from €152 round-trip by Iberia! Find the cheapest flights to South America from European cities and book your ticket at the best price! Flights will cost from €152 both ways.

South America is a vast, wedge-shaped continent stretching from the Caribbean to the Southern Ocean, home to the Andes—the world’s longest mountain range—the Amazon rainforest and river basin, the Atacama Desert, and the glacier-sculpted wilds of Patagonia. Its 12 countries (including Brazil, Argentina, Colombia, Peru, and Chile) blend Indigenous, European, and African influences, reflected in languages like Spanish, Portuguese, Quechua, and Guaraní, and in cuisines from Amazonian açaí to Argentine asado. Ancient Inca sites such as Machu Picchu sit alongside vibrant megacities like São Paulo, Buenos Aires, Bogotá, Lima, and Rio de Janeiro. One of Earth’s most biodiverse regions, South America pairs dramatic landscapes with rich cultures, music, and festivals.

Travel dates:

March – April 2027

Routes and examples:

Porto – Sao Paulo – Hamburg (186 EUR)
Lisbon – Sao Paulo – Munich (152 EUR)
Madrid – Sao Paulo – Dusseldorf (181 EUR)
Madrid – Sao Paulo – Munich (174 EUR)
Milan – Sao Paulo – Munich (192 EUR)
Zurich – Sao Paulo – Munich (174 EUR)
Lisbon – Sao Paulo – Zurich (158 EUR)
Brussels – Sao Paulo – Dusseldorf (179 EUR)
Brussels – Sao Paulo – Munich (189 EUR)
Barcelona – Sao Paulo – Munich (185 EUR)
Rome – Sao Paulo – Munich (202 EUR)
Lyon – Sao Paulo – Munich (186 EUR)
Vienna – Sao Paulo – Munich (315 EUR)
Valencia – Sao Paulo – Zurich (192 EUR)
Athens – Sao Paulo – Munich (297 EUR)
Oslo – Sao Paulo – Munich (373 EUR)
Stockholm – Sao Paulo – Munich (331 EUR)

Double open-jaw flights:

Porto – Panama | Sao Paulo – Hamburg  (248 EUR)
Milan – Panama | Sao Paulo – Hamburg  (311 EUR)
Porto – Sao Paulo | Santo Domingo – Dusseldorf  (226 EUR)
Madrid – Sao Paulo | Santo Domingo – Dusseldorf  (265 EUR)
Madrid – Panama | Sao Paulo – Hamburg  (290 EUR)
Zurich – Bogota | Sao Paulo – Hamburg (317 EUR)
Zurich – Bogota | Lima – Frankfurt (411 EUR)
Lisbon – Buenos Aires | Sao Paulo – Berlin (243 EUR)
Madrid – Buenos Aires | Sao Paulo – Munich (294 EUR)
Milan – Buenos Aires | Sao Paulo – Munich (252 EUR)
Milan – Bogota | Sao Paulo – Munich (245 EUR)
Milan – Costa Rica | Sao Paulo – Berlin  (357 EUR)
Zurich – Bogota | Lima – Frankfurt (455 EUR)

Baggage policy:

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Accommodation:

Agoda is transforming travel for millions of customers across the globe. Part of  Booking Holdings, Agoda is one of the world’s largest online travel accommodation platforms with a network of over 2,000,000 vacation rentals and hotels worldwide.

Cancelled or delayed flight?

If your flight is cancelled or delayed by 3+ hours, you may get a refund of up to €600. Check it out at SkyCop.

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Tours and excursions:

Discover and book unforgettable tours, activities, and attractions worldwide with GetYourGuide – your ultimate travel companion for authentic local experiences.

Have a look at Trip Advisor as well when planning your holiday to find out what’s hot and what’s not when it comes to all the local attractions.

Car rental:

You can find the best car rental prices at Economybookings.com.

Unlock amazing car rental deals in over 150 countries with EconomyBookings.com – your go-to platform for easy, affordable, and reliable car hire wherever your travels take you.